![]() If a person’s heart stops working effectively, their blood pressure will change. The pumping action of the heart helps maintain normal pressure within the blood vessels. Some people experience this type of edema because they have a rare condition known as systemic leaky capillary syndrome. If the capillaries cannot reabsorb the fluid, it will stay in the tissues, causing swelling and water retention. If these problems occur, too much liquid can leave the capillaries and enter the spaces between cells. Possible problems include changes in pressure inside the capillaries and the capillary walls becoming too leaky. If the capillaries sustain damage, edema can occur. After delivering the nutrients, the fluid returns to the capillaries. This fluid, called interstitial fluid, supplies nutrients and oxygen to cells. Some medications, such as those for high blood pressure, can cause damage to the capillaries.Ĭapillaries deliver fluid to surrounding tissues. Capillary damageĬapillaries are tiny blood vessels with a key role in managing fluid balance in the body. If there is a problem with any of these parts, the body may be unable to expel fluid as it should. Hormonal factors, the cardiovascular system, the urinary system, the liver, and the kidneys all play a role. The human body uses a complex system to regulate its water levels. Fluid retention caused by diazoxide may be treated with diuretics, if you develop this side effect.Share on Pinterest Thomas Barwick/Getty Images.One of the side effects diazoxide can cause is fluid retention, swollen and puffs lower arms and leg (edema) and congestive heart failure.Oral diazoxide is used to treat low blood glucose (hypoglycemia) caused by medical conditions that have too much insulin (hyperinsulinemia).The oral diazoxide works by reducing the amount of insulin that is released from the pancreas, so there is less insulin in the bloodstream, which means that the blood sugar levels will increase to a more normal level. The insulin in our body reduces the blood sugar levels, so in conditions that have an excess in insulin levels this causes low blood glucose levels. Oral diazoxide (Proglycem) is NOT used to treat occasional low blood sugar caused by diet. In infants and children the conditions are inoperable islet cell adenoma or carcinoma.The medical conditions in adults that cause this increase in insulin are Oral diazoxide (Proglycem) is used to increase blood sugar levels in patients that have low blood sugar that has been caused by specific medical conditions that increase the amount of insulin in the bloodstream. While on diazoxide, symptoms and signs of fluid retention need to be regularly evaluated.ĭue to this fluid retention side effect diazoxide should be used cautiously in patients with congestive heart failure or poor cardiac function, and these patients intensive monitoring.įor more information on other diazoxide side effects click here: diazoxide side effects What is oral diazoxide (Proglycem) used for? The addition of a thiazide diuretic may make the diazoxide more effective at increasing the blood sugar, so the diazoxide dose may need adjusting if you start taking a thiazide diuretic.Fluid retention may be treated with thiazide diuretics including chlorothiazide and hydrochlorothiazide.The fluid retained in the body can lead to swelling and puffiness of lower arms and legs (edema) and can lead to congestive heart failure if not managed properly. ![]() Diazoxide causes an unwanted increase in water and sodium retention which means the body accumulates extra fluid.Diazoxide and fluid retentionįluid retention is a clinically important and significant side effect of diazoxide. Should you use a diuretic with diazoxide?Ī diuretic may be required in some people who are on oral diazoxide, if they have developed the diazoxide side effects of fluid retention, edema or congestive heart failure.
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